Mohamed Elyounoussi and Theo Walcott will both miss the weekend after testing positive for Covid, the only two current cases at the club.
Will Smallbone and Tino Livramento are also out with injuries. Smallbone has a calf problem while Livramento is on his way back from a knee injury.
And Mali international Moussa Djenepo completes the list of Southampton’s unavailable players with the midfielder currently away at AFCON.
Kyle Walker-Peters and Yan Valery will return for the clash at Molineux after being suspended for Tuesday night’s win over Brentford.
So as we look ahead to the Premier League meeting (3pm), here is Southampton’s available squad in full:
Goalkeepers: Willy Caballero, Fraser Forster, Harry Lewis, Alex McCarthy.
Defenders: Jan Bednarek, Dare Olufunwa, Lyanco, Romain Perraud, Mohammed Salisu, Thierry Small, Jack Stephens, Yan Valery, Kyle Walker-Peters.
Midfielders: Kegs Chauke, Ibrahima Diallo, Nathan Redmond, Stuart Armstrong, Oriol Romeu, James Ward-Prowse.
Forwards: Adam Armstrong, Che Adams, Armando Broja, Shane Long, Kazeem Olaigbe, Nathan Tella.